*의약품 효력 시험

신약개발에서 효력의 측정은 모델동물과 약리학적 기전에대한 풍부한 지식이 필요하다. 본 연구실에서는 그동안 다음과 같은 모델동물을 이용하여 신물질들의 효력을 평가하였다.

  1. Hypercholesterolemia
  2. 뇌하수체적출랫트
  3. 누드마우스 및 syngenic mice를 이용한 종양이식
  4. 감염모델 (Helicobacter, Salmonella, E coli, Calicivirus)을 이용한 유산균의 효력시험
  5. 양을 이용한 악관절증
  6. 토끼를 이용한 슬관절증
  7. Collagen induced athritis in mice


1. Che JH, Lee YS, Park JH. 1997. Hypocholesterolemic Effects of LPSS-150 in Rats. Seoul Univ. J. Vet. Sci. 22. 51-55.
2. Lee BH, Kim YJ, Lee JH, Kim KY, Lee HS, Kim CH, Park JH, Choi ES, Tae JH, Park JH. 1998. Effect of Recombinant Human Growht Hormone(rhGH) on the Promotion of Body Weight Gain. Korean J. of Lab. Anim. Sci. 14. 61-76
3. Che JH, Chung DW, Noh SK, Lee YS, Park JH. 1998. Serum Cholesterol Lowering Effects of the Phytosterol Derivative(LPSS) in Rats Korean J. of Toxicol. and Pub. Health. 14. 535-540
4. Chang-Hwan Kim, Ju-Ho Tai,  Jong-Hwan Park, Sin Young  Kang, Seung-Jin Lee, Dae-Han Park Byung-Su Lee,  and Jae-Hak Park. Antitumor effect of recombinant interferon a-2a in nude mice. Korean J Lab Anim Sci 14(2) 251-255
5. Myung-Soon Baek, Jae-Hak Park, and Shien-Young Kang 1998 Antiviral and antitumor activities of recombinant human interferon-a Korean J Lab Anim Sci 14(2) 235-239.
6. Ma JY, Yang JM, Joo HJ, Lee MY, Park JH Jung KY, 1999. Improvement of cerebral ATP and choline deficiencis by Sha0-Yin-Ren Shi-Quang-Da-Bu-Tang in senescence-accelated mouse prone 8. J Ethnopharmacol. 67, 297-305
7. BC Kang, JH Park, et al 1999. Effect of AL072, a Novel Anti-Legionella Antibiotic, on Growth and cell morphology of Legionella pneumophila. J Biotech Microbiol 9, 371-375
8. JW Lee, CH KIM, JH Park, ES Choi, JG Hong, JS Park, Jae-Hak Park. 1999. Effect of sodium hyaluronate on osteoarthrosis in rabbit model. J Appl Pharmacol, 7(4):347-353.
9. Chang-Hwan Kim, Beom-Jun Lee, Yong-Soon Lee, and Jae-Hak Park. 2000. Antitumor Effects of Recombinant Human Interferon-2a Against Chronic Myelogenous Leukemia-Derived Cell Lines. Korean J Vet Res 40(1):166-172.
10. Chang-Hwan Kim*, Beom-Jun Lee1)*,  Junghee Yoon2), Kang-Mun Seo3), Jong-Hwan Park, Jin-Won Lee, Eun-Sil Choi, Jung-Ju Hong, Yong-Soon Lee1) and Jae-Hak Park. 2001.Therapeutic effect of hyaluronic acid on experimental osteoarthrosis of ovine temporomandibular joint  J Vet Med Sci 63(10) 1083-1089
11. Seung-Hyeok Seok, Jong-Hwan Park, Sun-A Cho and Jae-Hak Park. 2001. Comparison of hypercholesterolemia induced by Triton WR-1339 and high cholesterol diet. Korean J Lab Anim Sci 17(4)
12. Jong-Hwan Park,  Jung-Joo Hong, Eun-Sil Choi, Jin-Won Lee, Jae-Hak Park. 2001.Eficacy of typhoid vaccine produced by purifying Vi antigen of Salmonella typhi   submit

 

 

 

 

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Lab Anim Med, College of Vet Med, Seoul Nat'l Univ, Sinlim, Kwanak, Seoul, Korea 151-742