*전임상 시험

본 연구실에서는 신약 또는 신물질에 대하여 급성, 반복투여, 생식독성, 변이원성, 신경독성, 조류독성 시험을 수행하여 다음과 같은 결과를 얻었다.

1. Lee YS, Park JH, Kang TG, Kim HS, Cho MJ, You MY. 1987. Studies of recombinant human Interferon aA(rHuIFN-aA) on fertility in rats. Korean J Toxicol. 3. 33-44
2. YS Lee, JH Park, YB  Kim, JS Kim. 1988. Local irritation test of gamma human Interferon. Korean J Lab Ani Sci, 4, 47-55
3. Lee YS, Cho JJ, Kim YS, Nam JS, Park JH, Lee SB. 1994. Acute toxicity of DA-3030 (G-CSF) in rats and mice. J App Pharm 2, 256-259
4. Lee Ys, Cho JJ, Nam KH, Seo KW, Kang SG, Park JH, Kim WB. 1994. Four-week intravenous toxicity of DA-3030 (G-CSF) in beagle dogs. J App Pharm. 2, 260-269
5. Cho JJ, Kim YS, Nam JS, Che JH, Lee SM, Park JH, Lee YS. 1995, A study on ocular and skin irritation tests of shampoos and rinse. Korean J Lab Ani Sci, 11, 207-212
6. Lee YS, Cho JJ, Seo KW, Nam KH, Kim YS, Nam JS, M Miura, Che JH, Lee SM, Yang JM, Park JH. 1995. Four-week intravenous toxicity of LB00014 in beagle dogs. Koran J Lab Ani Sci. 11, 183-192
7. Lee YS, Cho JJ, Seo KW, Nam KH, Kim YS, Nam JS, M Miura, Che JH, Lee SM, Yang JM, Park JH. 1995. The study on four-week intravenous toxicity of erythropoietin in rabbits. Korean J Lab Ani Sci. 11. 175-182
8. Lee YS, Nam JS, Che JH, Lee SM, Yang JM, Kang BC, Lee HM, Park JH, Kang SA. 1996. Acute toxicity with the Ginkgo biloba extract (EGb 761) in rats and rabbits. Korean J Lab Ani Sci. 12. 131-134.
9. Lee YS, Nam JS, Che JH, Lee SM, Yang JM, Kang BC, Lee HM, Park JH, Kang SA. 1996. Peri- and post natal studies for Ginkgo biloba extract in rats. Korean J Lab Ani Sci. 12 123-130
10. Lee YS, Nam JS, Che JH, Lee SM, Yang JM, Kang BC, Lee HM, Kang SA, Park JH. 1996. Teratological studies of Ginkgo biloba extract (EGb 761) in rats. Korean J Lab Ani Sci. 12. 117-121.
11. Lee YS, Nam JS, Che JH, Lee SM, Yang JM, Kang BC, Lee HM, Park JH, Kim DY, Kang SA. Teratological studies of Ginkgo biloba extract (EBg 761) in rabbits. Korean J Toxicol. 12. 137-141
12. Lee YS, Nam JS, Che JH, Lee SM, Yang JM, Kang BC, Lee HM, Park JH, Kim DY, Kang SA. 1996. Fertility and general reproductive ability test of Ginkgo Biloba extract (EGb 761) in rats. Korean J Toxicol. 12. 129-136.
13. Lee YS, Nam JS, Che JH, Lee SM, Yang JM, Kang BC, Lee HM, Park JH, Chai CH, Kang SA. 1996. Three month subacute toxicity study of Ginkgo Biloba extract (EGb 761) in rabbits. Korean J Toxicol. 12. 121-128.
14. Lee YS, Nam JS, Che JH, Lee SM, Yang JM, Kang BC, Lee HM, Park JH, Chai CH, Kang SA. 1996. Three month subacute toxicity study of Ginkgo Biloba extract (EGb 761) in rats. Korean J Toxicol. 12. 113-119
15. Nam JS, Che JH, Lee SM, Yang JM, Kang BC, Lee HM, Park JH, Song DH, Yoo SH, Lee YS. 1997. Acute Toxicity Test with EPO(Erythroietin) in Rats and Beagle Dogs. Korean J. Toxicol. 13. 127-130.
16. Nam JS, Che JH, Lee SM, Yang JM, Kang BC, Lee HM, Park JH, Song DH, Yoo SH, Lee YS. 1997. Four-Week Intravenous Toxicity of EPO(Erythroietin) in Rat. Korean J. Toxicol. 13. 131-138.
17. Che JH, Nam JS, Yang JM, Lee SM, Kang BC, Lee HM, Park JH, Song DH, Yoo SH, Lee YS. 1997. Four-Week Intravenous Toxicity Studies of EPO(Erythroietin) in Rabbits. Korean J. Toxicol. 13. 139-147.
18. Kang BC, Nam JS, Che JH, Lee SM, Yang JM, Lee HM, Park JH, Song DH, Yoo SH, Lee YS. 1997. A Study on Ocular and Skin Irritation Test of EPO(Erythropoietin). Korean J. Toxicol. 13. 149-152.
19. Lee HM, Nam JS, Che JH, Lee SM, Yang JM, Kang BC, Park JH, Song DH, Yoo SH, Lee YS. 1997. Antigenicity of EPO(Erythropoietin) in Guinea Pigs, Mice and Rats. Korean J. Toxicol. 13. 153-156.
20. Nam KH, Park JH, Lee WK, S.Itagaki, K.Doi, Lee YS. 1997. Studies on Estabilishment of Non-surgical Medium-term Carcinogenicity Bioassay. Korean J. of Lab. Anim. Sci. 13. 9-24.
21. Kang BC, Lee JS, Lee JW, Nam JS, Che JH, Lee SM, Yang JM, Lee HM, Park JH, Lee YS. 1997. The Chromosomal Aberration Test of YH1885 in Chinese Hamster Ovary Cell In vitro. Korean J. of Lab. Anim. Sci. 13. 109-112.
22. Kang BC, Moon BS, Lee JW, Nam JS, Che JH, Lee SM, Yang JM, Lee HM, Park JH, Lee YS. 1997. The Micronucleus Test of YH1885 with Mice. Korean J. of Lab. Anim. Sci. 13. 113-116.
23. Park JH, Seo KW, Nam KH, Han SS, Lee YS. 1997. A study on acute delayed neurotoxicity of KH-502, A newly synthesized insecticide. Korean J. Toxicol. 13. 31-322
24. Kang BC. Lee HM, Che JH, Nam JS, Lee SM, Yang JM, Park JH, Lee YS. 1998. Evaluation of Immunotoxicities of New Skin Decontamination Kit(SDK) Korean J. of Toxicol. and Pub. Health. 14. 205-210
25. Jung JY, Lee WW, Ihm JH, Nam JS, Che JH, Li GH, Kang BC, Lee HM, Yi BH, Park JH, Lee YS. 1998. Mitagenecity Test of SDK Korean J. of Toxicol. and Pub. Health. 14. 211-216
26. Lee WW, Ihm JH, Jung JY, Nam JS, Che JH, Li GH, Kang BC, Lee HM, Lee BH, Park JH, Lee YS. 1998. Four-Week Topical Toxicology Studies of SDK in Beagle Dogs and Sprague-Dawley Rats Korean J. of Toxicol. and Pub. Health. 14. 217-226
27. Ihm JH, Nam JS, Che JH, Li GH, Lee HM, Lee WW, Yi BH, Jung JY, Park JH, Lee YS. 1998. A Study for Acute and Four-week Intravenous Toxicity Studies of Intralipidos Korean J. of Toxicol. and Pub. Health. 14. 435-442
28. Li GH, Che JH, Kang BH, Lee WW, Ihm JH, Jung JY, Yi BH, Man JS, Park JH, Lee YS. 1998. Acute Toxicity and Four-week Intravenous Toxicity Studies of Intralipidos Korean J. of Toxicol. and Pub. Health. 14. 443-452
29. Jung JY, Lee WWm Ihm JH, Nam JS, Che JH, Li GH, Knag BC, Yi BH, Park JH, Lee YS. 1998. Mutagenecity Test of Intralipidos Korean J. of Toxicol. and Pub. Health. 14. 453-458
30. JW Lee, CH KIM, JH Park, ES Choi, JG Hong, Jae-Hak Park. 1999. Toxicity test of sodium hyaluronate on Sprague-Dawley rats. J Toxicol Pub Health, 15(4):509-512.
31. Eun-Sil Choi, Jong-Hwan Park, Jung-Joo Hong, Jae-Hak Park 2001. Aute oral toxicity test in Japanese quail Korean J. of Toxicol. and Pub. Health. 17(4) 287-296

 

 

 

 

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Lab Anim Med, College of Vet Med, Seoul Nat'l Univ, Sinlim, Kwanak, Seoul, Korea 151-742